August 30, 2019

Saqib Islam
Chief Executive Officer
SpringWorks Therapeutics, Inc.
100 Washington Blvd
Stamford, CT 06902

       Re: SpringWorks Therapeutics, Inc.
           Response dated August 27, 2019
           File No. 333-233351

Dear Mr. Islam:

       We have reviewed your response and have the following comments. In some
of our
comments, we may ask you to provide us with information so we may better
understand your

       Please respond to these comments within ten business days by providing
the requested
information or advise us as soon as possible when you will respond. If you do
not believe our
comments apply to your facts and circumstances, please tell us why in your

       After reviewing your response to these comments, we may have additional

Response dated August 27, 2019


1.    Your indicate that all dollar amounts and per share amounts in your
response are
      presented on a pre-stock split basis. Please confirm whether this is also
true with respect
      to your estimated IPO price range. To the extent that both the estimated
price range and
      common stock valuations are presented on the same basis, please provide
us with further
      support for the significant increase from your most recent common stock
valuation date as
      of June 30, 2019.
 Saqib Islam
FirstName LastNameSaqib Islam
SpringWorks Therapeutics, Inc.
Comapany NameSpringWorks Therapeutics, Inc.
August 30, 2019
Page 2
August 30, 2019 Page 2
FirstName LastName
        You may contact Christine Torney at (202) 551-3652 or Angela Connell,
Accounting Branch Chief, at (202) 551-3426 if you have questions regarding
comments on the
financial statements and related matters. Please contact Tonya K. Aldave at
(202) 551-3601 or
Dietrich King at (202) 551-8071 with any other questions.


                                                           Division of
Corporation Finance
                                                           Office of Healthcare
& Insurance
cc:      Kingsley Taft, Esq.